HitPredict

Interactor 1: ARP3 (P61158)
Actin-related protein 3 (Actin-like protein 3)
Gene: ACTR3

Interactor 2: WASF2 (Q9Y6W5)
Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2)
Gene: WASF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	10381382, 34079125
Identification Methods	pull down, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Actin~WH2
Common GO terms	GO:0005829 - cytosol GO:0005911 - cell-cell junction GO:0010592 - positive regulation of lamellipodium assembly GO:0015629 - actin cytoskeleton GO:0030027 - lamellipodium and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 498
+	Hs
		896852 ARP3_HUMAN (1-418): 0: 588: 100.00		WASF3_HUMAN (1-498): 4.08e-58: 202: 46.92
+	Hs
		892150 ACTB_HUMAN (1-414): 0: 539: 35.66		WASF2_HUMAN (1-498): 3.76e-64: 218: 100.00
+	Hs
		930077 ACTG_HUMAN (1-414): 0: 538: 35.42		WASF2_HUMAN (1-498): 3.76e-64: 218: 100.00
+	Hs
		896793 ARP3_HUMAN (1-418): 0: 588: 100.00		WASF1_HUMAN (1-496): 3.22e-43: 162: 43.19
+	Hs
		932482 ACTC_HUMAN (3-414): 0: 527: 35.59		WASF2_HUMAN (1-498): 3.76e-64: 218: 100.00
+	Hs
		930055 ACTG_HUMAN (1-414): 0: 538: 35.42		WASF3_HUMAN (1-498): 4.08e-58: 202: 46.92
+	Hs
		929950 ACTG_HUMAN (1-414): 0: 538: 35.42		WASF1_HUMAN (1-496): 3.22e-43: 162: 43.19
+	Rn
		892225 ACTB_RAT (1-414): 0: 539: 35.66		WASF1_RAT (1-496): 1.76e-41: 157: 43.19
+	Hs
		203220 ACTC_HUMAN (3-414): 0: 527: 35.59		SYNJ1_HUMAN (36-496): 2.09e-41: 161: 13.30
+	Hs
		896792 ARP3_HUMAN (1-418): 0: 588: 100.00		TITIN_HUMAN (198-454): 8.71e-21: 98.9: 17.05
+	At
		1338960 ARP3_ARATH (6-417): 0: 523: 59.10		SCAR3_ARATH (1-162): 3.07e-40: 157: 22.75
+	Hs
		891942 ACTB_HUMAN (1-414): 0: 539: 35.66		CBP_HUMAN (38-468): 2.79e-27: 118: 12.79
+	Hs
		915464 ACTA_HUMAN (3-414): 0: 526: 35.59		CBP_HUMAN (38-468): 2.79e-27: 118: 12.79