HitPredict

Interactor 1: ARP2 (P61160)
Actin-related protein 2 (Actin-like protein 2)
Gene: ACTR2

Interactor 2: TWF1 (Q12792)
Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)
Gene: TWF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 394 Hs			1 350
+	Hs
		891728 ACTB_HUMAN (1-388): 0: 574: 46.65		TWF1_HUMAN (1-350): 5.66e-171: 481: 100.00
+	Hs
		891834 ACTB_HUMAN (1-388): 0: 574: 46.65		TWF2_HUMAN (1-344): 3.79e-159: 451: 65.41
+	Dm
		501533 ACT1_DROME (1-388): 0: 575: 45.88		TWF_DROME (1-344): 2.47e-146: 418: 48.84
+	Hs
		618041 ARP2_HUMAN (1-394): 0: 815: 100.00		COF1_HUMAN (4-142): 6.84e-37: 132: 17.09
+	Ce
		501473 ACT4_CAEEL (1-388): 0: 578: 46.91		ADF1_CAEEL (4-189): 4.06e-42: 147: 17.23
+	Hs
		891650 ACTB_HUMAN (1-388): 0: 574: 46.65		GMFB_HUMAN (178-312): 1.2e-41: 144: 21.43
+	Hs
		894697 ACTG_HUMAN (3-388): 0: 573: 46.37		GMFB_HUMAN (178-312): 1.2e-41: 144: 21.43
+	Hs
		891649 ACTB_HUMAN (1-388): 0: 574: 46.65		DEST_HUMAN (4-138): 2.63e-40: 141: 18.59
+	Hs
		894665 Q1KLZ0_HUMAN (1-388): 0: 574: 46.65		DEST_HUMAN (4-138): 2.63e-40: 141: 18.59
+	Hs
		894652 ACTG_HUMAN (3-388): 0: 573: 46.37		DEST_HUMAN (4-138): 2.63e-40: 141: 18.59
+	Hs
		1092828 Q1KLZ0_HUMAN (1-388): 0: 574: 46.65		Q549N0_HUMAN (4-138): 2.83e-38: 136: 17.53
+	Hs
		891817 ACTB_HUMAN (1-388): 0: 574: 46.65		Q549N0_HUMAN (4-138): 2.83e-38: 136: 17.53
+	Hs
		892124 ACTB_HUMAN (1-388): 0: 574: 46.65		COF2_HUMAN (4-138): 2.83e-38: 136: 17.53
+	Dm
		501443 ACT5_DROME (1-388): 0: 573: 45.62		CADF_DROME (4-144): 1.37e-38: 136: 17.45
+	Mm
		578583 ACTB_MOUSE (1-388): 0: 574: 46.65		COF1_MOUSE (4-142): 1.65e-37: 134: 17.09
+	Hs
		618038 ACTB_HUMAN (1-388): 0: 574: 46.65		COF1_HUMAN (4-142): 6.84e-37: 132: 17.09
+	Hs
		618096 Q1KLZ0_HUMAN (1-388): 0: 574: 46.65		COF1_HUMAN (4-142): 6.84e-37: 132: 17.09
+	Rn
		799735 ACTB_RAT (1-388): 0: 574: 46.65		COF1_RAT (4-142): 3.9e-37: 132: 17.09
+	Hs
		618049 ACTG_HUMAN (3-388): 0: 573: 46.37		COF1_HUMAN (4-142): 6.84e-37: 132: 17.09
+	Dm
		501459 ACT5_DROME (1-388): 0: 573: 45.62		Q9VWR1_DROME (4-143): 6.21e-36: 129: 21.19