HitPredict

Interactor 1: ACTZ (P61163)
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Gene: ACTR1A

Interactor 2: DCTN1 (Q14203)
Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Gene: DCTN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	26638075, 28514442, 33961781, 27173435, 34079125
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005875 - microtubule associated complex GO:0005938 - cell cortex and 1 others more... GO:0015630 - microtubule cytoskeleton
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 376 Hs			1 1278
+	Hs
		785540 ACTY_HUMAN (1-376): 0: 728: 90.43		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Dm
		528047 ACTZ_DROME (1-376): 0: 649: 79.26		DCTN1_DROME (23-1233): 4.05e-103: 358: 31.82
+	Hs
		891760 ACTB_HUMAN (7-376): 0: 580: 52.41		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		929862 ACTG_HUMAN (7-376): 0: 580: 52.67		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		915383 ACTA_HUMAN (5-376): 0: 576: 52.66		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		932151 ACTC_HUMAN (5-376): 0: 576: 52.93		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		675146 ACTZ_HUMAN (1-376): 0: 771: 100.00		CLIP1_HUMAN (111-828): 1.9e-21: 103: 11.32
+	Hs
		675128 ACTY_HUMAN (1-376): 0: 728: 90.43		CLIP1_HUMAN (111-828): 1.9e-21: 103: 11.32
+	Rn
		892236 ACTB_RAT (7-376): 0: 580: 52.41		MYH10_RAT (664-1275): 1.11e-22: 107: 10.46
+	Hs
		725136 ACTC_HUMAN (5-376): 0: 576: 52.93		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		725135 ACTH_HUMAN (7-376): 0: 572: 52.94		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		724738 ACTB_HUMAN (7-376): 0: 580: 52.41		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		724762 ACTG_HUMAN (7-376): 0: 580: 52.67		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Mm
		892205 ACTB_MOUSE (7-376): 0: 580: 52.41		MYH9_MOUSE (826-1275): 8.37e-15: 82.2: 10.13
+	Rn
		892228 ACTB_RAT (7-376): 0: 580: 52.41		MYH9_RAT (805-1277): 3.43e-14: 80.2: 12.76
+	Hs
		724766 ACTC_HUMAN (5-376): 0: 576: 52.93		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		724767 ACTS_HUMAN (5-376): 0: 576: 52.39		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Ce
		91038 Q9NA98_CAEEL (4-376): 0: 555: 70.24		E2JKZ0_CAEEL (42-637): 2.46e-12: 73.9: 15.00