HitPredict

Interactor 1: CSN2 (P61201)
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Gene: COPS2

Interactor 2: IRF8 (Q02556)
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP)
Gene: IRF8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.649

Property	Details
Experiments	10991940, 21903422
Identification Methods	pull down, two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 426
+	Hs
		971725 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		IRF8_HUMAN (1-426): 0: 587: 100.00
+	Hs
		897241 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		IRF5_HUMAN (9-414): 5.23e-156: 451: 30.36
+	Hs
		971751 CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25		IRF8_HUMAN (1-426): 0: 587: 100.00
+	Hs
		1024155 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		IRF5_HUMAN (9-414): 5.23e-156: 451: 30.36
+	Hs
		1039470 CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25		IRF5_HUMAN (9-414): 5.23e-156: 451: 30.36