HitPredict

Interactor 1: CSN2 (P61201)
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Gene: COPS2

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	23441852
Identification Methods	enzymatic study, pull down, acetylase assay
Interaction Type	direct interaction, acetylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 2414
+	Hs
		998723 PSMD6_HUMAN (55-440): 4.29e-87: 272: 13.01		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		998633 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		999036 CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		897279 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86
+	Hs
		897287 CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		1024193 CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02		PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86
+	Hs
		1262810 CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25		PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86