HitPredict

Interactor 1: RPAB2 (P61218)
DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide) (RPABC14.4) (RPB14.4) (RPB6 homolog) (RPC15)
Gene: POLR2F

Interactor 2: RPB7 (P62487)
DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19)
Gene: POLR2G

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.948

Property	Details
Experiments	26186194, 9201987, 24981860, 26496610, 33961781, 35271311
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RNA_pol_Rpb6~SHS2_Rpb7-N
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005665 - RNA polymerase II, core complex GO:0006366 - transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 127 Hs			1 172
+	Sp
		145812 RPAB2_SCHPO (1-124): 1.18e-45: 146: 51.75		RPB7_SCHPO (2-171): 1.24e-67: 205: 49.42
+	Sc
		593223 RPAB2_YEAST (2-126): 1.14e-46: 149: 49.65		RPB7_YEAST (1-171): 4.45e-63: 193: 42.78
+	Hs
		897672 RPAB2_HUMAN (1-127): 9.52e-51: 158: 100.00		RPC8_HUMAN (1-172): 5.28e-54: 171: 18.72
+	Sc
		593225 RPAB2_YEAST (2-126): 1.14e-46: 149: 49.65		RPC8_YEAST (1-158): 1.07e-49: 160: 19.39
+	Tb
		1104259 Q387N1_TRYB2 (35-126): 2.51e-30: 107: 28.57		Q381Y8_TRYB2 (1-171): 3.54e-49: 158: 23.16