HitPredict

Interactor 1: RAP2B (P61225)
Ras-related protein Rap-2b (EC 3.6.5.2)
Gene: RAP2B

Interactor 2: RPGF2 (Q9Y4G8)
Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
Gene: RAPGEF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10934204
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PDZ~Ras, RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction GO:0016020 - membrane GO:0032486 - Rap protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 1499
+	Hs
		919687 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF2_HUMAN (1-1499): 0: 1710: 100.00
+	Hs
		486041 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		919653 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		486052 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		RGL1_HUMAN (509-1169): 2.3e-123: 405: 15.46
+	Hs
		486024 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		GNDS_HUMAN (629-1169): 5.35e-110: 373: 15.33
+	Dm
		442976 RAP1_DROME (1-165): 7.45e-82: 241: 65.46		Q9VMF3_DROME (603-1176): 7.09e-123: 423: 39.48
+	Dm
		332231 O96692_DROME (1-183): 3.91e-77: 229: 67.76		Q9VMF3_DROME (603-1176): 7.09e-123: 423: 39.48
+	Hs
		919681 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RGL1_HUMAN (509-1169): 2.3e-123: 405: 15.46
+	Hs
		897981 RAP2B_HUMAN (1-183): 8.63e-88: 256: 100.00		GNDS_HUMAN (629-1169): 5.35e-110: 373: 15.33
+	Hs
		313164 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		RPGF3_HUMAN (598-1002): 1.1e-91: 321: 27.03
+	Hs
		919618 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		GNDS_HUMAN (629-1169): 5.35e-110: 373: 15.33
+	Hs
		897984 RAP2B_HUMAN (1-183): 8.63e-88: 256: 100.00		RPGF1_HUMAN (497-962): 7.1e-99: 345: 19.96
+	Dm
		51591 O96692_DROME (1-183): 3.91e-77: 229: 67.76		A1Z6P8_DROME (468-956): 7.28e-107: 366: 24.08
+	Ce
		1089983 RAP1_CAEEL (1-183): 1.66e-74: 223: 60.11		Q19770_CAEEL (619-1185): 8.16e-108: 359: 15.41
+	Hs
		919625 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF1_HUMAN (497-962): 7.1e-99: 345: 19.96
+	Hs
		313171 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF3_HUMAN (598-1002): 1.1e-91: 321: 27.03
+	Hs
		486045 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		RPGF5_HUMAN (268-471): 2.99e-35: 145: 15.26
+	Hs
		486043 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		RPGF4_HUMAN (110-234): 8.52e-19: 95: 21.21
+	Hs
		919657 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF5_HUMAN (268-471): 2.99e-35: 145: 15.26
+	Hs
		919656 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF4_HUMAN (110-234): 8.52e-19: 95: 21.21