HitPredict

Interactor 1: MAX (P61244)
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)
Gene: MAX

Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	17418410
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~PAS
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 160 Hs			1 870
+	Hs
		1079725 USF2_HUMAN (16-115): 1.18e-24: 99.1: 29.91		EPAS1_HUMAN (1-870): 0: 863: 100.00
+	Hs
		898132 MAX_HUMAN (1-160): 2.05e-31: 112: 100.00		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		346909 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Mm
		348427 MYC_MOUSE (19-105): 1.04e-21: 91.9: 37.50		HIF1A_MOUSE (3-787): 0: 549: 43.60
+	Hs
		126114 MAX_HUMAN (1-160): 2.05e-31: 112: 100.00		BMAL1_HUMAN (1-524): 1.58e-129: 403: 20.70
+	Hs
		181507 MAX_HUMAN (1-160): 2.05e-31: 112: 100.00		CLOCK_HUMAN (3-780): 7.98e-123: 393: 17.42
+	Hs
		345984 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		ARNT_HUMAN (2-644): 5.31e-129: 407: 19.24
+	Hs
		348397 MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74		NCOA3_HUMAN (6-565): 1.75e-97: 335: 17.47