HitPredict

Interactor 1: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Interactor 2: LHX4 (Q969G2)
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)
Gene: LHX4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.928

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781, 20211142, 31515488
Identification Methods affinity chromatography technology, two hybrid, two hybrid array, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Homeodomain~Homeodomain, LIM~LIM
Common GO terms GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0045944 - positive regulation of transcription by RNA polymerase II
and 1 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 349
Hs

1 390
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Last updated: 15 Jul 2024