HitPredict

Interactor 1: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Interactor 2: SSBP4 (Q9BWG4)
Single-stranded DNA-binding protein 4
Gene: SSBP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	26186194, 28514442, 33961781, 24981860, 20211142
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 349 Hs			1 385
+	Hs
		1283495 ISL2_HUMAN (1-349): 3.08e-80: 250: 73.35		SSBP4_HUMAN (1-385): 6e-71: 228: 100.00
+	Hs
		899933 ISL1_HUMAN (1-349): 1.96e-89: 274: 100.00		SSBP3_HUMAN (6-385): 7.32e-54: 184: 70.03
+	Mm
		899944 ISL1_MOUSE (1-349): 1.96e-89: 274: 100.00		SSBP3_MOUSE (6-385): 7.32e-54: 184: 70.03
+	Mm
		1112383 ISL2_MOUSE (1-349): 4.08e-80: 250: 72.21		Q3U4B1_MOUSE (1-385): 1.89e-54: 185: 83.68
+	Hs
		1283496 ISL2_HUMAN (1-349): 3.08e-80: 250: 73.35		SSBP3_HUMAN (6-385): 7.32e-54: 184: 70.03
+	Mm
		1321868 ISL2_MOUSE (1-349): 4.08e-80: 250: 72.21		SSBP3_MOUSE (6-385): 7.32e-54: 184: 70.03
+	Mm
		899943 ISL1_MOUSE (1-349): 1.96e-89: 274: 100.00		SSBP2_MOUSE (1-385): 5.05e-44: 157: 69.77
+	Hs
		899917 ISL1_HUMAN (1-349): 1.96e-89: 274: 100.00		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Hs
		839818 LHX2_HUMAN (3-316): 1.86e-58: 195: 25.55		SSBP4_HUMAN (1-385): 6e-71: 228: 100.00
+	Hs
		1314654 LHX9_HUMAN (3-304): 5.38e-58: 194: 26.27		SSBP4_HUMAN (1-385): 6e-71: 228: 100.00
+	Hs
		822672 LHX1_HUMAN (16-349): 3.6e-57: 192: 27.35		SSBP4_HUMAN (1-385): 6e-71: 228: 100.00
+	Mm
		1321867 ISL2_MOUSE (1-349): 4.08e-80: 250: 72.21		SSBP2_MOUSE (1-385): 5.05e-44: 157: 69.77
+	Hs
		946656 ISL2_HUMAN (1-349): 3.08e-80: 250: 73.35		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Mm
		1321929 LHX2_MOUSE (3-316): 2.14e-59: 198: 25.82		SSBP3_MOUSE (6-385): 7.32e-54: 184: 70.03
+	Hs
		839819 LHX2_HUMAN (3-316): 1.86e-58: 195: 25.55		SSBP3_HUMAN (6-385): 7.32e-54: 184: 70.03
+	Hs
		1314903 LHX9_HUMAN (3-304): 5.38e-58: 194: 26.27		SSBP3_HUMAN (6-385): 7.32e-54: 184: 70.03
+	Hs
		822674 LHX1_HUMAN (16-349): 3.6e-57: 192: 27.35		SSBP3_HUMAN (6-385): 7.32e-54: 184: 70.03
+	Mm
		1321891 LHX2_MOUSE (3-316): 2.14e-59: 198: 25.82		SSBP2_MOUSE (1-385): 5.05e-44: 157: 69.77
+	Hs
		839725 LHX2_HUMAN (3-316): 1.86e-58: 195: 25.55		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Hs
		822624 LHX1_HUMAN (16-349): 3.6e-57: 192: 27.35		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51