HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0030027 - lamellipodium GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 377
+	Hs
		900364 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		891672 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		925178 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		436249 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		915362 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		ACTA_HUMAN (1-377): 0: 596: 100.00
+	Hs
		545292 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		915593 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		915594 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		ACTS_HUMAN (1-377): 0: 598: 97.88