HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: BORG5 (Q00587)
Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55)
Gene: CDC42EP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007266 - Rho protein signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 391
+	Hs
		925198 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		436256 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		950927 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		893907 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		545325 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		892320 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		915611 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		120391 RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98		BORG5_HUMAN (1-391): 1.77e-158: 452: 100.00
+	Hs
		900891 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		925610 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		951333 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		894420 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		545611 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		892591 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		915970 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		120638 RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98		BORG4_HUMAN (25-280): 3.94e-67: 218: 30.54
+	Hs
		150124 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		BORG1_HUMAN (33-217): 2.72e-53: 177: 32.09
+	Hs
		894571 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		BORG2_HUMAN (33-218): 6.27e-48: 165: 27.85
+	Hs
		894139 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		BORG3_HUMAN (38-67): 9.1e-09: 55.7: 86.67