HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0071902 - positive regulation of protein serine/threonine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 393
+	Hs
		925211 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00
+	Hs
		647858 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		647868 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		734901 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		734906 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		436165 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		647872 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		625333 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		647856 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		681775 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Hs
		545213 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		734900 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		436162 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		915619 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00
+	Hs
		647855 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		647867 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		120307 RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Ce
		104466 G5EBV3_CAEEL (2-193): 1.08e-77: 232: 50.52		Q304D8_CAEEL (38-366): 4.1e-104: 315: 30.42
+	Ce
		104472 G5EBV3_CAEEL (2-193): 1.08e-77: 232: 50.52		CST1_CAEEL (38-366): 1.04e-102: 314: 30.42
+	Hs
		805371 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69