HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 32203420, 31871319
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PDZ~Ras, PH~Ras, RBD~Ras, Ras~RhoGEF
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007160 - cell-matrix adhesion
GO:0016477 - cell migration
GO:0032587 - ruffle membrane
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 193
Hs

1 1591
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024