HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	9199174, 31871319, 15545284
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1025
+	Hs
		900771 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		CNKR1_HUMAN (351-693): 2.42e-66: 239: 21.04
+	Hs
		925705 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		SWP70_HUMAN (370-824): 7.27e-58: 212: 19.22
+	Hs
		900722 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		925457 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		436422 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		925603 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		TARA_HUMAN (231-985): 1.44e-51: 201: 35.57
+	Hs
		925356 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MRCKG_HUMAN (599-998): 1.13e-44: 178: 19.48
+	Hs
		148608 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		900922 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		148653 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		925629 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		148297 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		254464 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ROCK2_HUMAN (446-1018): 6.09e-17: 88.7: 11.81
+	Hs
		724757 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		900884 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SLK_HUMAN (178-999): 9.15e-17: 87.8: 10.02
+	Hs
		254468 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ROCK2_HUMAN (446-1018): 6.09e-17: 88.7: 11.81
+	Hs
		254433 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ROCK2_HUMAN (446-1018): 6.09e-17: 88.7: 11.81
+	Hs
		724776 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		436499 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		SLK_HUMAN (178-999): 9.15e-17: 87.8: 10.02
+	Hs
		254472 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		ROCK2_HUMAN (446-1018): 6.09e-17: 88.7: 11.81