HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ARHGI (Q6ZSZ5)
Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)
Gene: ARHGEF18

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.755

Property	Details
Experiments	11085924, 34591642
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	PH_16~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization GO:0030054 - cell junction and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1361
+	Hs
		900679 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARG28_HUMAN (52-1284): 2.53e-129: 440: 32.78
+	Hs
		900417 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		AKP13_HUMAN (16-1282): 1.69e-108: 382: 30.91
+	Sp
		1000081 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF2_SCHPO (72-964): 2.18e-87: 312: 13.29
+	Hs
		900765 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG1_HUMAN (249-812): 7.94e-95: 328: 25.21
+	Mm
		650205 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		RGRF1_MOUSE (206-1028): 2.47e-83: 301: 12.46
+	Sp
		1000083 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF3_SCHPO (429-762): 7.64e-70: 259: 22.73
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (374-820): 2.39e-79: 282: 17.66
+	Hs
		900718 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX1_HUMAN (401-889): 2.18e-73: 272: 14.48
+	Hs
		900616 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX2_HUMAN (425-890): 8.06e-73: 270: 14.29
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (251-1002): 1.18e-72: 269: 17.57
+	Hs
		156395 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RGRF2_HUMAN (210-1009): 4.97e-72: 266: 11.73
+	Hs
		900546 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG4_HUMAN (27-835): 3.45e-71: 263: 12.84
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (361-859): 2.26e-72: 262: 15.05
+	Hs
		900636 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG8_HUMAN (356-815): 1.96e-66: 238: 17.15
+	Sc
		419716 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		ROM2_YEAST (420-718): 1.56e-39: 162: 21.87
+	Hs
		279851 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TRIO_HUMAN (189-1018): 2.31e-51: 202: 11.74
+	Sp
		1000084 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF1_SCHPO (361-781): 5.64e-40: 164: 17.50
+	Sp
		1336810 RHO5_SCHPO (4-193): 1.09e-93: 273: 65.31		RGF1_SCHPO (361-781): 5.64e-40: 164: 17.50
+	Hs
		297123 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG5_HUMAN (427-801): 3.97e-41: 167: 20.40
+	Mm
		1146468 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		PKHG5_MOUSE (427-924): 1.56e-39: 162: 19.13