HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31871319, 22072711
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0001764 - neuron migration GO:0005886 - plasma membrane GO:0070507 - regulation of microtubule cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 788
+	Hs
		925384 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		436371 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		951102 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		894157 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		545461 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		892447 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		647858 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647868 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		436165 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647872 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647856 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		545213 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647855 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		894319 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		MARK4_HUMAN (3-788): 0: 572: 48.20
+	Hs
		925283 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MELK_HUMAN (44-788): 7.75e-161: 483: 25.03
+	Hs
		894016 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		MELK_HUMAN (44-788): 7.75e-161: 483: 25.03
+	Hs
		545381 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		MELK_HUMAN (44-788): 7.75e-161: 483: 25.03
+	Hs
		894405 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		SIK2_HUMAN (34-733): 3.78e-144: 448: 31.08
+	Rn
		871208 RHOA_RAT (1-193): 4.1e-81: 240: 99.48		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00
+	Rn
		871319 RAC1_RAT (1-193): 8.86e-80: 237: 57.22		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00