HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: LRC8D (Q7L1W4)
Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D)
Gene: LRRC8D

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 858
+	Hs
		900463 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SCRIB_HUMAN (398-763): 2.93e-61: 228: 23.91
+	Hs
		925273 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		SCRIB_HUMAN (398-763): 2.93e-61: 228: 23.91
+	Hs
		436297 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		SCRIB_HUMAN (398-763): 2.93e-61: 228: 23.91
+	Hs
		950989 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		SCRIB_HUMAN (398-763): 2.93e-61: 228: 23.91
+	Hs
		893999 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		SCRIB_HUMAN (398-763): 2.93e-61: 228: 23.91
+	Hs
		545370 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		SCRIB_HUMAN (398-763): 2.93e-61: 228: 23.91
+	Dm
		776889 RAC1_DROME (1-193): 2.11e-77: 231: 54.12		SCRIB_DROME (603-858): 2.23e-55: 210: 25.78
+	Hs
		900824 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ERBIN_HUMAN (388-652): 1.4e-27: 122: 14.43
+	Hs
		925539 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ERBIN_HUMAN (388-652): 1.4e-27: 122: 14.43
+	Hs
		436472 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ERBIN_HUMAN (388-652): 1.4e-27: 122: 14.43
+	Hs
		951251 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		ERBIN_HUMAN (388-652): 1.4e-27: 122: 14.43
+	Hs
		894337 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		ERBIN_HUMAN (388-652): 1.4e-27: 122: 14.43
+	Hs
		925299 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RSU1_HUMAN (576-771): 3.86e-11: 66.6: 29.65
+	Hs
		900667 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		LRC8A_HUMAN (733-858): 2.37e-09: 63.1: 14.50
+	Hs
		925419 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		LRC8A_HUMAN (733-858): 2.37e-09: 63.1: 14.50
+	Dm
		776906 RAC1_DROME (1-193): 2.11e-77: 231: 54.12		Q9V428_DROME (627-801): 3.03e-11: 67: 27.86
+	Hs
		436394 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		LRC8A_HUMAN (733-858): 2.37e-09: 63.1: 14.50
+	Hs
		951139 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		LRC8A_HUMAN (733-858): 2.37e-09: 63.1: 14.50
+	Hs
		894196 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		LRC8A_HUMAN (733-858): 2.37e-09: 63.1: 14.50
+	Hs
		545486 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		LRC8A_HUMAN (733-858): 2.37e-09: 63.1: 14.50