HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PHLB2 (Q86SQ0)
Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)
Gene: PHLDB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0070507 - regulation of microtubule cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1253
+	Hs
		925400 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PHLB2_HUMAN (1-1253): 7.85e-124: 415: 100.00
+	Hs
		436377 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PHLB2_HUMAN (1-1253): 7.85e-124: 415: 100.00
+	Hs
		724757 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MYH9_HUMAN (242-1165): 8.89e-36: 150: 10.57
+	Hs
		724776 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		MYH9_HUMAN (242-1165): 8.89e-36: 150: 10.57
+	Hs
		297820 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		K0754_HUMAN (42-1075): 9.75e-20: 98.6: 8.66
+	Hs
		148608 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		CTRO_HUMAN (529-1124): 1.75e-19: 97.5: 10.68
+	Hs
		297823 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		K0754_HUMAN (42-1075): 9.75e-20: 98.6: 8.66
+	Hs
		148653 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		CTRO_HUMAN (529-1124): 1.75e-19: 97.5: 10.68
+	Hs
		297809 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		K0754_HUMAN (42-1075): 9.75e-20: 98.6: 8.66
+	Hs
		725138 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		MYH10_HUMAN (164-906): 2.35e-20: 100: 9.92
+	Hs
		148297 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		CTRO_HUMAN (529-1124): 1.75e-19: 97.5: 10.68
+	Hs
		297827 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		K0754_HUMAN (42-1075): 9.75e-20: 98.6: 8.66
+	Hs
		254464 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ROCK2_HUMAN (699-1134): 2.23e-10: 67.5: 11.90
+	Mm
		823539 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		CTRO_MOUSE (288-791): 1.77e-09: 64.7: 11.99
+	Hs
		254468 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ROCK2_HUMAN (699-1134): 2.23e-10: 67.5: 11.90
+	Rn
		92842 RHOA_RAT (1-193): 4.1e-81: 240: 99.48		CTRO_RAT (270-791): 2.15e-09: 64.3: 11.49
+	Mm
		823530 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		CTRO_MOUSE (288-791): 1.77e-09: 64.7: 11.99
+	Hs
		254433 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ROCK2_HUMAN (699-1134): 2.23e-10: 67.5: 11.90
+	Hs
		254472 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		ROCK2_HUMAN (699-1134): 2.23e-10: 67.5: 11.90
+	Mm
		823529 CDC42_MOUSE (1-193): 5.51e-77: 230: 52.33		CTRO_MOUSE (288-791): 1.77e-09: 64.7: 11.99