HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: FMNL3 (Q8IVF7)
Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)
Gene: FMNL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1028
+	Hs
		900815 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMNL2_HUMAN (1-1025): 0: 986: 66.94
+	Hs
		925531 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FMNL2_HUMAN (1-1025): 0: 986: 66.94
+	Hs
		901084 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DAAM1_HUMAN (19-1015): 0: 713: 21.56
+	Hs
		925759 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DAAM1_HUMAN (19-1015): 0: 713: 21.56
+	Hs
		900958 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DIAP3_HUMAN (92-1012): 0: 635: 20.42
+	Hs
		925658 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DIAP3_HUMAN (92-1012): 0: 635: 20.42
+	Hs
		243097 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DIAP2_HUMAN (48-1015): 0: 610: 19.83
+	Hs
		243100 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DIAP2_HUMAN (48-1015): 0: 610: 19.83
+	Hs
		314854 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMNL1_HUMAN (557-1025): 1.53e-142: 456: 57.45
+	Hs
		314858 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FMNL1_HUMAN (557-1025): 1.53e-142: 456: 57.45
+	Hs
		900981 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMN2_HUMAN (516-965): 2.32e-106: 367: 18.09
+	Hs
		925673 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FMN2_HUMAN (516-965): 2.32e-106: 367: 18.09
+	Hs
		900525 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		INF2_HUMAN (537-1021): 7.68e-103: 352: 21.98
+	Hs
		925315 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		INF2_HUMAN (537-1021): 7.68e-103: 352: 21.98
+	Hs
		436333 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		INF2_HUMAN (537-1021): 7.68e-103: 352: 21.98
+	Hs
		925768 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FHOD1_HUMAN (557-1021): 2.01e-99: 341: 18.52
+	Hs
		237579 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DIAP1_HUMAN (104-507): 1.29e-82: 294: 18.09
+	Hs
		237586 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DIAP1_HUMAN (104-507): 1.29e-82: 294: 18.09
+	Hs
		237551 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		DIAP1_HUMAN (104-507): 1.29e-82: 294: 18.09
+	Sc
		419707 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		BNI1_YEAST (570-962): 1.41e-16: 87.4: 24.07