HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ARHGJ (Q8IW93)
Rho guanine nucleotide exchange factor 19 (Ephexin-2)
Gene: ARHGEF19

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	32203420, 18256687
Identification Methods	fluorescent resonance energy transfer, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0032956 - regulation of actin cytoskeleton organization GO:0060071 - Wnt signaling pathway, planar cell polarity pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 802
+	Hs
		900416 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG5_HUMAN (4-801): 4.36e-124: 409: 37.67
+	Hs
		900690 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		NGEF_HUMAN (113-790): 8e-124: 389: 31.41
+	Hs
		900786 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGQ_HUMAN (5-792): 1.53e-117: 377: 25.83
+	Hs
		302670 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGF_HUMAN (243-801): 1.64e-99: 329: 32.98
+	Hs
		900947 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG4_HUMAN (102-743): 1.3e-99: 325: 13.38
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (271-737): 1.17e-93: 313: 15.42
+	Hs
		548678 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		VAV_HUMAN (271-737): 1.17e-93: 313: 15.42
+	Hs
		900916 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ECT2_HUMAN (246-801): 6.02e-92: 310: 17.78
+	Hs
		900985 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGC_HUMAN (187-750): 6.75e-88: 306: 14.58
+	Sp
		1000084 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF1_SCHPO (332-699): 1.09e-74: 267: 20.60
+	Sp
		1336810 RHO5_SCHPO (4-193): 1.09e-93: 273: 65.31		RGF1_SCHPO (332-699): 1.09e-74: 267: 20.60
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (128-743): 1.07e-84: 297: 14.86
+	Hs
		167081 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ARHGB_HUMAN (128-743): 1.07e-84: 297: 14.86
+	Hs
		901085 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FARP1_HUMAN (134-762): 1.08e-84: 293: 14.99
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (270-737): 4.44e-85: 291: 14.23
+	Hs
		900616 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX2_HUMAN (362-716): 1.22e-81: 288: 16.40
+	Sp
		1000083 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF3_SCHPO (372-739): 1.89e-61: 227: 20.05
+	Hs
		900948 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG3_HUMAN (267-705): 7.39e-77: 260: 20.44
+	Hs
		224711 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		KALRN_HUMAN (365-801): 9.95e-72: 259: 14.77
+	Hs
		297123 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG5_HUMAN (368-719): 3.38e-61: 225: 21.28