HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ARG28 (Q8N1W1)
Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor)
Gene: ARHGEF28

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, PH_16~Ras, Ras~RhoGEF
Common GO terms	GO:0000902 - cell morphogenesis GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1705
+	Hs
		900417 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		AKP13_HUMAN (1-814): 3.86e-122: 429: 17.82
+	Hs
		900612 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGI_HUMAN (366-1514): 8.24e-108: 378: 34.48
+	Hs
		900768 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG2_HUMAN (615-1525): 1.22e-103: 358: 35.81
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (303-1384): 8.38e-89: 322: 16.16
+	Sp
		1000084 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF1_SCHPO (411-1199): 8.04e-77: 283: 13.15
+	Sp
		1336810 RHO5_SCHPO (4-193): 1.09e-93: 273: 65.31		RGF1_SCHPO (411-1199): 8.04e-77: 283: 13.15
+	Sp
		1000083 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF3_SCHPO (425-1247): 2.74e-72: 268: 13.95
+	Hs
		900530 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG6_HUMAN (718-1470): 2.43e-82: 291: 16.62
+	Hs
		900765 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG1_HUMAN (499-1351): 7.21e-81: 289: 18.20
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (747-1459): 1.5e-75: 273: 11.68
+	Hs
		900813 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGH_HUMAN (391-1384): 1.6e-72: 271: 15.35
+	Hs
		900947 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG4_HUMAN (815-1275): 1.7e-76: 271: 15.32
+	Hs
		900786 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGQ_HUMAN (503-1193): 1.49e-74: 269: 14.09
+	Hs
		156395 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RGRF2_HUMAN (612-1424): 4.29e-71: 264: 12.73
+	Mm
		650205 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		RGRF1_MOUSE (625-1431): 4.32e-70: 261: 13.09
+	Hs
		506561 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		BCR_HUMAN (401-1283): 7.4e-70: 260: 13.08
+	Hs
		900636 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG8_HUMAN (735-1217): 1.2e-72: 257: 17.84
+	Hs
		900948 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG3_HUMAN (742-1232): 1.44e-72: 254: 19.34
+	Sc
		419716 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		ROM2_YEAST (819-1138): 2.08e-52: 205: 22.75
+	Hs
		279851 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TRIO_HUMAN (838-1573): 4.57e-40: 166: 12.58