HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: CNKR1 (Q969H4)
Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like)
Gene: CNKSR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.815

Property	Details
Experiments	14749388, 15670823
Identification Methods	pull down, two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0005938 - cell cortex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 720
+	Hs
		900386 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SPTB2_HUMAN (12-538): 1.01e-75: 268: 13.64
+	Hs
		925201 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		SPTB2_HUMAN (12-538): 1.01e-75: 268: 13.64
+	Hs
		436258 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		SPTB2_HUMAN (12-538): 1.01e-75: 268: 13.64
+	Hs
		164593 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SPTN2_HUMAN (12-552): 1.63e-50: 193: 13.76
+	Hs
		164599 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		SPTN2_HUMAN (12-552): 1.63e-50: 193: 13.76
+	Hs
		164556 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		SPTN2_HUMAN (12-552): 1.63e-50: 193: 13.76
+	Hs
		900922 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHA5_HUMAN (330-717): 1.02e-47: 184: 15.74
+	Hs
		925629 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PKHA5_HUMAN (330-717): 1.02e-47: 184: 15.74
+	Hs
		900564 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG21_HUMAN (93-687): 1.28e-37: 153: 14.13
+	Hs
		900925 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHA1_HUMAN (319-601): 3.5e-39: 151: 14.29
+	Hs
		901000 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG23_HUMAN (132-661): 4.27e-37: 151: 10.20
+	Hs
		925343 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RHG21_HUMAN (93-687): 1.28e-37: 153: 14.13
+	Hs
		925632 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PKHA1_HUMAN (319-601): 3.5e-39: 151: 14.29
+	Hs
		925690 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RHG23_HUMAN (132-661): 4.27e-37: 151: 10.20
+	Hs
		436517 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PKHA1_HUMAN (319-601): 3.5e-39: 151: 14.29
+	Hs
		900634 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG22_HUMAN (373-711): 1.02e-35: 145: 16.16
+	Hs
		925394 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RHG22_HUMAN (373-711): 1.02e-35: 145: 16.16
+	Hs
		900902 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHA4_HUMAN (383-502): 7.85e-26: 115: 26.40
+	Hs
		925616 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PKHA4_HUMAN (383-502): 7.85e-26: 115: 26.40
+	Mm
		925805 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		RHG22_MOUSE (370-521): 1.48e-14: 79.6: 19.65