HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ARHGH (Q96PE2)
Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)
Gene: ARHGEF17

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	32203420, 31871319
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 2063
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (529-1767): 7.24e-101: 361: 13.52
+	Hs
		900768 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG2_HUMAN (858-1740): 6.2e-104: 360: 14.74
+	Hs
		167081 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ARHGB_HUMAN (529-1767): 7.24e-101: 361: 13.52
+	Mm
		650205 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		RGRF1_MOUSE (874-1678): 7.42e-99: 351: 13.20
+	Hs
		506561 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		BCR_HUMAN (661-1507): 8.04e-93: 333: 18.96
+	Hs
		900786 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGQ_HUMAN (613-1411): 4.49e-92: 322: 16.25
+	Hs
		279851 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TRIO_HUMAN (1049-1752): 4.34e-78: 291: 14.01
+	Hs
		279854 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		TRIO_HUMAN (1049-1752): 4.34e-78: 291: 14.01
+	Hs
		164112 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGA_HUMAN (799-2021): 4.97e-75: 278: 12.40
+	Hs
		900718 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX1_HUMAN (1039-1431): 1.2e-74: 278: 23.91
+	Hs
		164115 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ARHGA_HUMAN (799-2021): 4.97e-75: 278: 12.40
+	Hs
		900616 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX2_HUMAN (1045-1367): 1.16e-73: 275: 25.00
+	Hs
		224711 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		KALRN_HUMAN (1043-1788): 7.56e-71: 267: 12.89
+	Hs
		900916 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ECT2_HUMAN (984-1451): 4.6e-72: 263: 20.70
+	Mm
		925798 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		BCR_MOUSE (855-1495): 2.7e-68: 256: 21.67
+	Hs
		900426 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ABR_HUMAN (1014-1472): 2.86e-68: 251: 21.66
+	Mm
		925793 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		ABR_MOUSE (1014-1472): 8.06e-69: 252: 21.70
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (1000-1350): 1.81e-67: 248: 21.63
+	Hs
		901037 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV3_HUMAN (1046-1323): 6.41e-18: 92.8: 27.72
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (1065-1328): 1.92e-15: 84.7: 26.57