HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: GDIR3 (Q99819)
Rho GDP-dissociation inhibitor 3 (Rho GDI 3) (Rho-GDI gamma)
Gene: ARHGDIG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9113980
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007266 - Rho protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 225
+	Hs
		925561 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		GDIR3_HUMAN (1-225): 1.49e-115: 330: 100.00
+	Hs
		951270 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		GDIR3_HUMAN (1-225): 1.49e-115: 330: 100.00
+	Hs
		894357 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		GDIR3_HUMAN (1-225): 1.49e-115: 330: 100.00
+	Rn
		901290 RHOA_RAT (1-193): 4.1e-81: 240: 99.48		GDIR1_RAT (36-225): 6.84e-105: 302: 60.53
+	Hs
		854763 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Mm
		925816 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		GDIR1_MOUSE (36-225): 6.84e-105: 302: 60.53
+	Hs
		854769 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		436218 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		854771 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		854760 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		545278 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		854851 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		GDIR2_HUMAN (47-225): 5.49e-96: 280: 60.89
+	Hs
		854852 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		GDIR2_HUMAN (47-225): 5.49e-96: 280: 60.89
+	Hs
		545279 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		GDIR2_HUMAN (47-225): 5.49e-96: 280: 60.89
+	Sc
		419734 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		GDIR_YEAST (47-222): 8.14e-70: 213: 36.41
+	At
		1105129 RAC3_ARATH (1-193): 2.48e-85: 251: 49.00		GDIR_ARATH (27-223): 4.23e-80: 241: 28.64
+	Dm
		816393 RHO1_DROME (1-193): 2.84e-76: 228: 86.53		Q9VW59_DROME (28-223): 7.56e-84: 249: 42.21
+	Ce
		975573 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		GDIR_CAEEL (47-222): 9.12e-76: 228: 37.29
+	Ce
		1093791 RHO1_CAEEL (1-192): 2.25e-75: 226: 85.94		GDIR_CAEEL (47-222): 9.12e-76: 228: 37.29
+	Cl
		47354 RAC1_CANLF (1-193): 8.86e-80: 237: 57.22		A0A8I3N6C6_CANLF (36-225): 9.11e-70: 212: 44.21