HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: IFT22 (Q9H7X7)
Intraflagellar transport protein 22 homolog (Rab-like protein 5)
Gene: IFT22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~Roc
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 185
+	Hs
		900355 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB1A_HUMAN (4-172): 1.57e-68: 208: 14.62
+	Hs
		900882 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB1B_HUMAN (4-172): 4.12e-68: 207: 14.62
+	Hs
		918847 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAB1A_HUMAN (4-172): 1.57e-68: 208: 14.62
+	Hs
		925600 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAB1B_HUMAN (4-172): 4.12e-68: 207: 14.62
+	Hs
		436244 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		RAB1A_HUMAN (4-172): 1.57e-68: 208: 14.62
+	Hs
		436498 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		RAB1B_HUMAN (4-172): 4.12e-68: 207: 14.62
+	Hs
		918849 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		RAB1A_HUMAN (4-172): 1.57e-68: 208: 14.62
+	Hs
		893872 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		RAB1A_HUMAN (4-172): 1.57e-68: 208: 14.62
+	Hs
		894710 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB8A_HUMAN (4-177): 1.34e-64: 199: 15.91
+	Hs
		894409 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		RAB1B_HUMAN (4-172): 4.12e-68: 207: 14.62
+	Hs
		545307 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		RAB1A_HUMAN (4-172): 1.57e-68: 208: 14.62
+	Hs
		894716 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAB8A_HUMAN (4-177): 1.34e-64: 199: 15.91
+	Hs
		436230 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		RAB8A_HUMAN (4-177): 1.34e-64: 199: 15.91
+	Hs
		894720 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		RAB8A_HUMAN (4-177): 1.34e-64: 199: 15.91
+	Hs
		893847 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		RAB8A_HUMAN (4-177): 1.34e-64: 199: 15.91
+	Hs
		545295 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		RAB8A_HUMAN (4-177): 1.34e-64: 199: 15.91
+	Hs
		892297 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		RAB8A_HUMAN (4-177): 1.34e-64: 199: 15.91
+	Hs
		925186 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ARF5_HUMAN (3-147): 2.3e-55: 174: 22.07
+	Hs
		912848 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		ARF6_HUMAN (3-145): 4.21e-54: 171: 17.48
+	Hs
		574649 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		ARF4_HUMAN (3-145): 1.16e-32: 116: 20.98