HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	34901393, 17719543, 20026602, 21402695
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0060071 - Wnt signaling pathway, planar cell polarity pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 748
+	Mm
		56825 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		SMUF2_MOUSE (1-748): 0: 835: 99.20
+	Hs
		900929 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Rn
		88544 RHOA_RAT (1-193): 4.1e-81: 240: 99.48		D3ZCF5_RAT (1-748): 0: 733: 70.97
+	Hs
		808080 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		925397 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		HUWE1_HUMAN (114-747): 0: 589: 31.46
+	Hs
		925423 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		HACE1_HUMAN (61-742): 8.87e-167: 505: 25.15
+	Hs
		125308 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		125349 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		125100 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		125372 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		125298 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		900802 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		125135 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		925520 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		436457 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		125294 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		951237 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		894313 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		545560 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		892540 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44