HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: DIAP3 (Q9NSV4)
Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2)
Gene: DIAPH3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	31871319, 15085137
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization GO:0032154 - cleavage furrow
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1193
+	Hs
		925658 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DIAP3_HUMAN (1-1193): 0: 1085: 100.00
+	Hs
		901084 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DAAM1_HUMAN (87-1104): 0: 757: 26.00
+	Hs
		925759 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DAAM1_HUMAN (87-1104): 0: 757: 26.00
+	Hs
		436379 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		DAAM2_HUMAN (94-1104): 0: 737: 25.09
+	Hs
		900661 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMNL3_HUMAN (92-1091): 0: 665: 20.44
+	Hs
		900815 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMNL2_HUMAN (112-1089): 0: 653: 21.45
+	Hs
		925531 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FMNL2_HUMAN (112-1089): 0: 653: 21.45
+	Hs
		237579 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DIAP1_HUMAN (20-635): 3.9e-134: 442: 37.97
+	Hs
		237586 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DIAP1_HUMAN (20-635): 3.9e-134: 442: 37.97
+	Hs
		237551 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		DIAP1_HUMAN (20-635): 3.9e-134: 442: 37.97
+	Hs
		243097 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DIAP2_HUMAN (48-556): 9.03e-132: 432: 58.29
+	Hs
		243100 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DIAP2_HUMAN (48-556): 9.03e-132: 432: 58.29
+	Hs
		900525 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		INF2_HUMAN (612-1179): 3.52e-123: 412: 22.30
+	Hs
		925315 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		INF2_HUMAN (612-1179): 3.52e-123: 412: 22.30
+	Hs
		436333 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		INF2_HUMAN (612-1179): 3.52e-123: 412: 22.30
+	Hs
		925768 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FHOD1_HUMAN (130-1175): 1.1e-113: 384: 15.79
+	Hs
		900981 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMN2_HUMAN (595-1059): 8.72e-101: 354: 24.08
+	Hs
		925673 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FMN2_HUMAN (595-1059): 8.72e-101: 354: 24.08
+	Hs
		314854 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMNL1_HUMAN (116-548): 1.04e-80: 289: 17.78
+	Hs
		314858 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FMNL1_HUMAN (116-548): 1.04e-80: 289: 17.78