HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ARHGC (Q9NZN5)
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
Gene: ARHGEF12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	28514442, 11373293, 32203420, 33961781, 31871319, 23405219, 34591642, 15364580, 20300064
Identification Methods	affinity chromatography technology, pull down, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PDZ~Ras, PH_16~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0007266 - Rho protein signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1544
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (48-1455): 2.54e-146: 489: 30.06
+	Hs
		900765 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG1_HUMAN (339-1284): 2.31e-106: 363: 32.74
+	Hs
		900768 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG2_HUMAN (557-1462): 1.89e-101: 351: 17.54
+	Hs
		900417 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		AKP13_HUMAN (623-1216): 1.04e-92: 336: 23.13
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (673-1294): 1.01e-96: 334: 15.63
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (714-1339): 2.94e-93: 325: 13.81
+	Hs
		900679 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARG28_HUMAN (154-1467): 1.55e-87: 318: 14.37
+	Hs
		900612 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGI_HUMAN (517-1176): 7.39e-88: 317: 20.74
+	Hs
		900690 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		NGEF_HUMAN (512-1200): 1.23e-90: 312: 17.07
+	Hs
		166479 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MCF2L_HUMAN (384-1307): 1.05e-85: 308: 14.27
+	Mm
		650205 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		RGRF1_MOUSE (588-1375): 6e-84: 304: 13.55
+	Mm
		1146468 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		PKHG5_MOUSE (611-1150): 2.68e-83: 299: 20.10
+	Hs
		297123 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG5_HUMAN (611-1245): 1.82e-82: 296: 19.74
+	Sp
		1000081 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF2_SCHPO (733-1136): 3.43e-70: 260: 21.58
+	Hs
		900786 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGQ_HUMAN (744-1139): 4.69e-83: 294: 19.17
+	Hs
		900530 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG6_HUMAN (718-1160): 7.26e-72: 259: 20.09
+	Hs
		279851 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TRIO_HUMAN (776-1451): 2.3e-60: 232: 13.39
+	Sc
		419716 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		ROM2_YEAST (760-1053): 3.1e-14: 80.5: 26.06
+	Sp
		1000083 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF3_SCHPO (785-1056): 8.97e-15: 82.4: 26.43
+	Hs
		900636 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG8_HUMAN (769-965): 3.23e-14: 79.7: 30.46