HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PLXA1 (Q9UIW2)
Plexin-A1 (Semaphorin receptor NOV)
Gene: PLXNA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Plexin_cytopl~Ras, Plexin_RBD~Ras, Ras~TIG
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030334 - regulation of cell migration GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1896
+	Hs
		925714 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		436563 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		951446 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		894567 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		545690 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		165182 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165187 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165146 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165189 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165180 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165155 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165179 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Dm
		776907 RAC1_DROME (1-193): 2.11e-77: 231: 54.12		PLXB_DROME (45-1109): 0: 848: 27.10
+	Dm
		816387 RHO1_DROME (1-193): 2.84e-76: 228: 86.53		PLXB_DROME (45-1109): 0: 848: 27.10
+	Dm
		819748 RAC2_DROME (1-193): 7.08e-75: 225: 53.61		PLXB_DROME (45-1109): 0: 848: 27.10
+	Hs
		900707 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SEM6D_HUMAN (8-543): 7.26e-123: 417: 15.57
+	Hs
		925450 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		SEM6D_HUMAN (8-543): 7.26e-123: 417: 15.57
+	Hs
		441478 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MET_HUMAN (814-1212): 1.56e-103: 367: 25.80
+	Hs
		436125 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		MET_HUMAN (814-1212): 1.56e-103: 367: 25.80
+	Hs
		195972 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PLXB1_HUMAN (558-875): 1.91e-12: 75.2: 18.58