HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: AGAP1 (Q9UPQ3)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)
Gene: AGAP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	22453919
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ank_2~Ras, Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 857
+	Hs
		925736 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		AGAP1_HUMAN (1-857): 0: 850: 100.00
+	Hs
		900834 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		AGAP2_HUMAN (52-827): 0: 597: 52.94
+	Hs
		925551 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		AGAP2_HUMAN (52-827): 0: 597: 52.94
+	Hs
		925724 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ASAP1_HUMAN (367-855): 1.34e-86: 300: 20.87
+	Hs
		900896 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		Q9H4D1_HUMAN (376-855): 5.28e-87: 295: 16.17
+	Hs
		900746 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Hs
		925478 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Gg
		1154344 Q6LC82_CHICK (1-193): 8.86e-80: 237: 57.22		Q9DG15_CHICK (622-848): 1.04e-73: 258: 32.78
+	Hs
		925274 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		GIT2_HUMAN (616-823): 7.46e-74: 258: 33.33
+	Hs
		925751 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		GIT1_HUMAN (616-848): 2.84e-73: 257: 31.58
+	Hs
		950990 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		GIT2_HUMAN (616-823): 7.46e-74: 258: 33.33
+	Hs
		951478 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		GIT1_HUMAN (616-848): 2.84e-73: 257: 31.58
+	Hs
		900355 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		918847 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		436244 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		897874 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAP1B_HUMAN (69-229): 7.97e-70: 230: 22.75
+	Hs
		918849 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		897878 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAP1B_HUMAN (69-229): 7.97e-70: 230: 22.75
+	Hs
		436236 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		RAP1B_HUMAN (69-229): 7.97e-70: 230: 22.75
+	Hs
		883465 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RIPK4_HUMAN (566-798): 1.5e-13: 76.7: 13.81