HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: NISCH (Q9Y2I1)
Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)
Gene: NISCH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1504
+	Hs
		925746 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		951470 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		900678 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		S11IP_HUMAN (129-540): 2.54e-55: 213: 23.61
+	Hs
		436398 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		S11IP_HUMAN (129-540): 2.54e-55: 213: 23.61
+	Hs
		951146 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		S11IP_HUMAN (129-540): 2.54e-55: 213: 23.61
+	Hs
		951135 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		CEP97_HUMAN (221-554): 1.17e-54: 209: 25.85
+	Hs
		900857 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		LGR4_HUMAN (100-537): 1.25e-40: 165: 15.65
+	Hs
		925580 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		LGR4_HUMAN (100-537): 1.25e-40: 165: 15.65
+	Hs
		436488 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		LGR4_HUMAN (100-537): 1.25e-40: 165: 15.65
+	Dm
		776889 RAC1_DROME (1-193): 2.11e-77: 231: 54.12		SCRIB_DROME (229-691): 1.82e-38: 159: 16.77
+	Hs
		900538 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DNAL1_HUMAN (299-414): 1.76e-36: 138: 31.03
+	Hs
		900667 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		LRC8A_HUMAN (209-418): 2.58e-21: 103: 21.82
+	Hs
		925419 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		LRC8A_HUMAN (209-418): 2.58e-21: 103: 21.82
+	Hs
		436394 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		LRC8A_HUMAN (209-418): 2.58e-21: 103: 21.82
+	Hs
		951139 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		LRC8A_HUMAN (209-418): 2.58e-21: 103: 21.82
+	Hs
		900463 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		925273 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		436297 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		950989 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		893999 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01