HitPredict

Interactor 1: COPZ1 (P61923)
Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP)
Gene: COPZ1

Interactor 2: ARF5 (P84085)
ADP-ribosylation factor 5
Gene: ARF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 35844135
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006886 - intracellular protein transport GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 177 Hs			1 180
+	Hs
		902292 COPZ1_HUMAN (1-177): 2.64e-68: 207: 100.00		ARF6_HUMAN (5-179): 5.26e-74: 221: 64.00
+	Hs
		574639 COPZ1_HUMAN (1-177): 2.64e-68: 207: 100.00		ARF4_HUMAN (1-180): 3.62e-70: 212: 90.00
+	Dm
		778371 Q8IQP2_DROME (16-177): 1.24e-52: 167: 63.19		ARF4_DROME (1-180): 1.02e-77: 231: 83.89
+	Hs
		913025 AP3S1_HUMAN (13-172): 7.45e-54: 171: 22.02		ARF6_HUMAN (5-179): 5.26e-74: 221: 64.00
+	Sc
		503119 COPZ_YEAST (5-175): 1.27e-47: 155: 35.14		ARF1_YEAST (1-179): 4.21e-78: 232: 69.83
+	Hs
		887138 AP3S2_HUMAN (13-172): 3.73e-52: 166: 22.02		ARF6_HUMAN (5-179): 5.26e-74: 221: 64.00
+	Hs
		574721 AP3S1_HUMAN (13-172): 7.45e-54: 171: 22.02		ARF4_HUMAN (1-180): 3.62e-70: 212: 90.00
+	Hs
		950672 AP3S1_HUMAN (13-172): 7.45e-54: 171: 22.02		ARF5_HUMAN (1-180): 1.69e-69: 210: 100.00
+	Hs
		574635 AP3S2_HUMAN (13-172): 3.73e-52: 166: 22.02		ARF4_HUMAN (1-180): 3.62e-70: 212: 90.00
+	Hs
		897392 AP3S1_HUMAN (13-172): 7.45e-54: 171: 22.02		ARF3_HUMAN (1-180): 4.68e-67: 204: 78.89
+	Hs
		887139 AP3S2_HUMAN (13-172): 3.73e-52: 166: 22.02		ARF1_HUMAN (1-180): 3.45e-67: 204: 80.56