HitPredict

Interactor 1: GBG11 (P61952)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gene: GNG11

Interactor 2: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	19168127, 7665596, 16301321, 12782285
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	G-gamma~WD40
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 73 Hs			1 340
+	Hs
		921515 GBG1_HUMAN (1-73): 5.67e-24: 86.9: 75.68		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		929139 GBG1_HUMAN (1-73): 5.67e-24: 86.9: 75.68		Q6FHM2_HUMAN (1-340): 1e-105: 314: 90.29
+	Bt
		362122 GBG1_BOVIN (1-73): 1.98e-24: 88.1: 75.68		GBB1_BOVIN (1-340): 7.02e-105: 312: 100.00
+	Hs
		902497 GBG11_HUMAN (1-73): 3.72e-24: 87.3: 100.00		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		920931 GBG1_HUMAN (1-73): 5.67e-24: 86.9: 75.68		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		929145 GBG1_HUMAN (1-73): 5.67e-24: 86.9: 75.68		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		560869 GBG11_HUMAN (1-73): 3.72e-24: 87.3: 100.00		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		560871 GBG1_HUMAN (1-73): 5.67e-24: 86.9: 75.68		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		229238 GBG7_HUMAN (16-72): 1.88e-22: 83.1: 42.11		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		837687 GBG10_HUMAN (13-72): 1.62e-22: 83.1: 35.00		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		921761 GBG12_HUMAN (16-72): 4.09e-22: 82.3: 45.61		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		229237 GBG7_HUMAN (16-72): 1.88e-22: 83.1: 42.11		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		229245 GBG7_HUMAN (16-72): 1.88e-22: 83.1: 42.11		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		837686 GBG10_HUMAN (13-72): 1.62e-22: 83.1: 35.00		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		837704 GBG10_HUMAN (13-72): 1.62e-22: 83.1: 35.00		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		921073 GBG12_HUMAN (16-72): 4.09e-22: 82.3: 45.61		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		229235 GBG7_HUMAN (16-72): 1.88e-22: 83.1: 42.11		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		560865 GBG10_HUMAN (13-72): 1.62e-22: 83.1: 35.00		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		560893 GBG12_HUMAN (16-72): 4.09e-22: 82.3: 45.61		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		154646 GBG7_HUMAN (16-72): 1.88e-22: 83.1: 42.11		GNB5_HUMAN (129-340): 1.35e-45: 161: 21.46