HitPredict

Interactor 1: SUMO2 (P61956)
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Gene: SUMO2

Interactor 2: SENP5 (Q96HI0)
Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5)
Gene: SENP5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16608850
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Peptidase_C48~Rad60-SLD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 95 Hs			1 755
+	Hs
		879147 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		SENP5_HUMAN (1-755): 0: 1139: 100.00
+	Xl
		78631 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		B6RQN8_XENLA (343-755): 1.22e-121: 383: 60.28
+	Hs
		902760 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP2_HUMAN (397-754): 1.54e-112: 355: 25.89
+	Hs
		879156 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		SENP2_HUMAN (397-754): 1.54e-112: 355: 25.89
+	Hs
		902778 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP1_HUMAN (368-754): 6.01e-109: 347: 25.64
+	Hs
		879158 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		SENP1_HUMAN (368-754): 6.01e-109: 347: 25.64
+	Hs
		928203 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		SENP2_HUMAN (397-754): 1.54e-112: 355: 25.89
+	Sp
		140841 PMT3_SCHPO (7-93): 4.62e-37: 122: 50.58		ULP1_SCHPO (316-753): 4.7e-105: 334: 21.38
+	Xl
		1151579 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		Q804S7_XENLA (275-754): 5.16e-98: 317: 22.64
+	Xl
		1140103 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		Q5XG28_XENLA (424-753): 1.84e-95: 306: 46.43
+	Hs
		902753 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP3_HUMAN (420-753): 7.1e-90: 295: 45.51
+	Dm
		332584 O97102_DROME (1-94): 1.24e-37: 123: 68.09		Q9VWK5_DROME (477-753): 1.1e-70: 254: 28.23
+	Sp
		140818 PMT3_SCHPO (7-93): 4.62e-37: 122: 50.58		ULP2_SCHPO (422-752): 2.12e-63: 225: 18.33
+	Sp
		140842 PMT3_SCHPO (7-93): 4.62e-37: 122: 50.58		NESP1_SCHPO (555-728): 1.01e-30: 127: 17.19
+	Hs
		902747 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP6_HUMAN (647-745): 7.5e-20: 97.2: 26.47
+	Xl
		80968 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		B7TYL1_XENLA (647-752): 6.57e-20: 97.2: 23.53
+	Hs
		902739 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP7_HUMAN (655-745): 4.34e-18: 91.4: 25.53
+	Mm
		1160381 SUMO3_MOUSE (1-94): 5.48e-43: 137: 95.75		SENP6_MOUSE (647-752): 2.1e-18: 92.6: 24.37
+	Xl
		80969 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		B7TYL2_XENLA (655-745): 5.83e-16: 84.5: 25.53
+	Hs
		928190 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		SENP6_HUMAN (647-745): 7.5e-20: 97.2: 26.47