HitPredict

Interactor 1: SUMO2 (P61956)
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Gene: SUMO2

Interactor 2: UBP28 (Q96RU2)
Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)
Gene: USP28

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.629

Property	Details
Experiments	26268556, 19615732
Identification Methods	x-ray crystallography, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 95 Hs			1 1077
+	Hs
		902795 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBP25_HUMAN (1-1068): 0: 977: 48.38
+	Hs
		879163 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		UBP25_HUMAN (1-1068): 0: 977: 48.38
+	Hs
		928224 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		UBP25_HUMAN (1-1068): 0: 977: 48.38
+	Hs
		800569 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBP5_HUMAN (28-649): 4.98e-77: 273: 12.71
+	Hs
		902655 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBP48_HUMAN (145-399): 5.66e-73: 264: 26.52
+	Hs
		902707 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		USP9X_HUMAN (136-452): 1.14e-61: 233: 18.33
+	Hs
		902708 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBP7_HUMAN (547-839): 8.01e-23: 107: 20.13
+	Hs
		902780 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBP36_HUMAN (473-649): 5.03e-09: 62.7: 17.98