HitPredict

Interactor 1: SUMO2 (P61956)
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Gene: SUMO2

Interactor 2: SENP6 (Q9GZR1)
Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6)
Gene: SENP6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	21148299, 17000875
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Peptidase_C48~Rad60-SLD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 95 Hs			1 1112
+	Hs
		928190 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		SENP6_HUMAN (1-1112): 0: 1617: 100.00
+	Mm
		1160381 SUMO3_MOUSE (1-94): 5.48e-43: 137: 95.75		SENP6_MOUSE (1-1109): 0: 1559: 78.79
+	Xl
		80968 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		B7TYL1_XENLA (6-1112): 0: 1354: 50.74
+	Hs
		902739 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP7_HUMAN (932-1085): 1.35e-60: 228: 50.00
+	Xl
		80969 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		B7TYL2_XENLA (950-1087): 1.32e-54: 208: 45.00
+	Sp
		140818 PMT3_SCHPO (7-93): 4.62e-37: 122: 50.58		ULP2_SCHPO (359-896): 7.41e-60: 219: 19.42
+	Hs
		902778 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP1_HUMAN (525-782): 1.67e-50: 191: 23.08
+	Hs
		879158 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		SENP1_HUMAN (525-782): 1.67e-50: 191: 23.08
+	Hs
		928213 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		SENP1_HUMAN (525-782): 1.67e-50: 191: 23.08
+	Xl
		1151579 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		Q804S7_XENLA (525-833): 7.5e-43: 168: 18.93
+	Hs
		902760 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP2_HUMAN (613-776): 8.7e-43: 167: 25.00
+	Hs
		879156 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		SENP2_HUMAN (613-776): 8.7e-43: 167: 25.00
+	Xl
		1140103 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		Q5XG28_XENLA (589-865): 1.1e-39: 155: 16.78
+	Hs
		928203 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		SENP2_HUMAN (613-776): 8.7e-43: 167: 25.00
+	Hs
		902753 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP3_HUMAN (589-865): 1.52e-34: 142: 16.43
+	Sp
		140841 PMT3_SCHPO (7-93): 4.62e-37: 122: 50.58		ULP1_SCHPO (614-785): 4.79e-37: 149: 20.12
+	Xl
		78631 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		B6RQN8_XENLA (668-863): 2.12e-28: 124: 18.05
+	Hs
		902714 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP5_HUMAN (668-863): 1.3e-27: 122: 16.59
+	Hs
		879147 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		SENP5_HUMAN (668-863): 1.3e-27: 122: 16.59
+	Dm
		332584 O97102_DROME (1-94): 1.24e-37: 123: 68.09		Q9VWK5_DROME (602-833): 1.06e-28: 127: 21.49