HitPredict

Interactor 1: SUMO2 (P61956)
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Gene: SUMO2

Interactor 2: SENP2 (Q9HC62)
Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2)
Gene: SENP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.877

Property	Details
Experiments	25416956, 19394292, 17099700
Identification Methods	two hybrid, pull down, x-ray crystallography, enzymatic study, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Peptidase_C48~Rad60-SLD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 95 Hs			1 589
+	Hs
		879156 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		SENP2_HUMAN (1-589): 0: 786: 100.00
+	Hs
		928203 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		SENP2_HUMAN (1-589): 0: 786: 100.00
+	Hs
		902778 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP1_HUMAN (203-589): 3.75e-114: 355: 40.00
+	Xl
		1151579 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		Q804S7_XENLA (207-589): 8.62e-114: 354: 39.30
+	Hs
		879158 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		SENP1_HUMAN (203-589): 3.75e-114: 355: 40.00
+	Hs
		902753 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP3_HUMAN (131-588): 1.25e-97: 310: 23.13
+	Hs
		902714 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP5_HUMAN (211-589): 8.52e-93: 302: 26.23
+	Hs
		879147 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		SENP5_HUMAN (211-589): 8.52e-93: 302: 26.23
+	Xl
		78631 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		B6RQN8_XENLA (121-589): 8.36e-90: 294: 23.00
+	Xl
		1140103 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		Q5XG28_XENLA (232-588): 5.56e-91: 289: 23.22
+	Sp
		140841 PMT3_SCHPO (7-93): 4.62e-37: 122: 50.58		ULP1_SCHPO (22-588): 1.25e-91: 294: 23.12
+	Dm
		332584 O97102_DROME (1-94): 1.24e-37: 123: 68.09		Q9VWK5_DROME (97-588): 3.24e-81: 280: 23.49
+	Sp
		140818 PMT3_SCHPO (7-93): 4.62e-37: 122: 50.58		ULP2_SCHPO (243-587): 2.13e-66: 229: 17.47
+	Hs
		902739 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP7_HUMAN (366-588): 7.5e-47: 178: 18.87
+	Xl
		80968 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		B7TYL1_XENLA (479-587): 1.14e-20: 98.8: 21.67
+	Mm
		1160381 SUMO3_MOUSE (1-94): 5.48e-43: 137: 95.75		SENP6_MOUSE (262-587): 1.62e-20: 98.4: 13.78
+	Hs
		902747 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		SENP6_HUMAN (479-587): 1.15e-19: 95.7: 22.50
+	Xl
		80969 SMO2B_XENLA (1-95): 1.18e-43: 138: 96.84		B7TYL2_XENLA (487-588): 6.32e-14: 77.2: 21.24
+	Hs
		928190 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		SENP6_HUMAN (479-587): 1.15e-19: 95.7: 22.50
+	Sp
		140842 PMT3_SCHPO (7-93): 4.62e-37: 122: 50.58		NESP1_SCHPO (390-563): 8.07e-16: 81.8: 19.68