HitPredict

Interactor 1: SUMO2 (P61956)
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Gene: SUMO2

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.786

Property	Details
Experiments	19217413, 16524884
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005654 - nucleoplasm GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 95 Hs			1 628
+	Hs
		879167 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		928241 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Mm
		222291 SUMO1_MOUSE (1-93): 7.76e-35: 116: 45.36		PIAS3_MOUSE (1-628): 0: 867: 96.98
+	Hs
		278020 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278009 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278040 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278253 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278250 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278256 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Rn
		1140374 SUMO3_RAT (1-94): 2.04e-42: 135: 95.75		PIAS2_RAT (1-528): 0: 626: 59.71
+	Hs
		902668 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		879136 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Rn
		78200 SUMO3_RAT (1-94): 2.04e-42: 135: 95.75		B5DFF9_RAT (2-443): 7.68e-174: 505: 50.45
+	Hs
		928135 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Rn
		78199 SUMO1_RAT (1-93): 7.76e-35: 116: 45.36		B5DFF9_RAT (2-443): 7.68e-174: 505: 50.45
+	Dm
		332592 O97102_DROME (1-94): 1.24e-37: 123: 68.09		Q9XYM5_DROME (10-519): 2.07e-161: 474: 42.34
+	At
		1147334 SUMO2_ARATH (3-93): 5.57e-38: 124: 51.65		SIZ1_ARATH (5-623): 1.75e-120: 380: 21.29
+	At
		1147333 SUMO3_ARATH (1-94): 1.6e-36: 120: 40.43		SIZ1_ARATH (5-623): 1.75e-120: 380: 21.29
+	At
		878961 SUMO1_ARATH (1-91): 8.61e-36: 118: 47.25		SIZ1_ARATH (5-623): 1.75e-120: 380: 21.29
+	Rn
		89025 SUMO3_RAT (1-94): 2.04e-42: 135: 95.75		D4AE97_RAT (79-422): 2.72e-84: 287: 24.93