HitPredict

Interactor 1: DCAF7 (P61962)
DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)
Gene: DCAF7

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	27705803, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 342 Hs			1 406
+	Mm
		903076 DCAF7_MOUSE (1-342): 5.45e-87: 267: 100.00		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Hs
		903005 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Mm
		1194979 Q80ZU1_MOUSE (1-342): 2.67e-85: 262: 99.71		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Mm
		1141971 RBBP7_MOUSE (10-342): 1.03e-68: 222: 14.51		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Mm
		1141950 RBBP4_MOUSE (10-342): 2.39e-68: 221: 13.98		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Hs
		997870 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		718385 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37
+	Hs
		903007 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		903017 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		903014 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		902923 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		PCGF3_HUMAN (34-224): 6.2e-39: 141: 17.53
+	Hs
		749311 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		902951 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		PCGF5_HUMAN (31-147): 4.96e-38: 139: 23.33
+	Hs
		718223 SC31B_HUMAN (23-336): 4.36e-52: 187: 17.38		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		997828 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		RN138_HUMAN (31-190): 6.27e-46: 160: 18.68
+	Hs
		749539 RBBP7_HUMAN (10-342): 1.27e-68: 222: 14.51		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		749420 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		302262 SC31A_HUMAN (23-342): 1.55e-55: 197: 17.56		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		749764 SNR40_HUMAN (116-342): 3.78e-43: 154: 13.66		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Dm
		1279331 EBI_DROME (104-342): 5.77e-41: 153: 15.98		Q9VV77_DROME (33-129): 1.77e-37: 137: 27.00