HitPredict

Interactor 1: DCAF7 (P61962)
DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)
Gene: DCAF7

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0030674 - protein-macromolecule adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 342 Hs			1 780
+	Hs
		902908 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		902909 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		902910 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		1041672 RBBP7_HUMAN (10-342): 1.27e-68: 222: 14.51		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		997713 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		1043016 RBBP7_HUMAN (10-342): 1.27e-68: 222: 14.51		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		902907 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		CUL2_HUMAN (6-780): 0: 699: 26.36
+	Hs
		997714 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		1043376 RBBP7_HUMAN (10-342): 1.27e-68: 222: 14.51		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		997715 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		302286 SC31A_HUMAN (23-342): 1.55e-55: 197: 17.56		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Ce
		953926 LIN53_CAEEL (10-342): 2.97e-67: 218: 14.88		CUL1_CAEEL (4-780): 0: 694: 25.34
+	Hs
		1043157 SNR40_HUMAN (116-342): 3.78e-43: 154: 13.66		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		1043509 SNR40_HUMAN (116-342): 3.78e-43: 154: 13.66		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	At
		186930 MSI1_ARATH (17-342): 3.99e-58: 195: 15.00		CUL4_ARATH (16-780): 0: 694: 24.09
+	Hs
		903207 WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Ce
		953927 LIN53_CAEEL (10-342): 2.97e-67: 218: 14.88		CUL2_CAEEL (7-780): 0: 646: 24.85
+	Hs
		903206 WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85		CUL1_HUMAN (11-780): 0: 748: 27.84
+	Hs
		903208 WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		903209 WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85		CUL4B_HUMAN (16-780): 0: 736: 25.39