HitPredict

Interactor 1: DCAF7 (P61962)
DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)
Gene: DCAF7

Interactor 2: DYR1B (Q9Y463)
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase)
Gene: DYRK1B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

Property	Details
Experiments	27307198, 28514442, 27705803, 14593110, 33961781, 35016035, 20940704, 32707033, 21777625, 23602568
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 342 Hs			1 629
+	Hs
		902911 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Hs
		997716 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Hs
		902983 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		DYRK2_HUMAN (9-492): 1.61e-117: 364: 34.09
+	Dm
		830253 Q9VR53_DROME (2-342): 2.69e-78: 244: 85.67		MNB_DROME (26-441): 1.9e-122: 386: 76.02
+	Hs
		625294 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		CDK2_HUMAN (108-376): 5.32e-119: 357: 27.82
+	Hs
		302287 SC31A_HUMAN (23-342): 1.55e-55: 197: 17.56		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Sp
		251855 YBE8_SCHPO (8-342): 7.34e-73: 233: 34.73		PPK15_SCHPO (7-502): 2.69e-120: 369: 33.27
+	Hs
		997923 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		DYRK4_HUMAN (4-542): 1.03e-119: 367: 32.22
+	At
		1105866 TTG1_ARATH (12-342): 1.11e-70: 225: 51.47		KSG7_ARATH (111-475): 9.76e-115: 349: 27.11
+	Hs
		1044099 GRWD1_HUMAN (206-342): 9.29e-18: 85.5: 17.61		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Ce
		1259285 Q93759_CAEEL (5-293): 8.74e-25: 106: 12.99		MBK1_CAEEL (30-499): 2.63e-122: 385: 51.90
+	Hs
		903402 WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85		DYRK2_HUMAN (9-492): 1.61e-117: 364: 34.09
+	Hs
		903022 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		HIPK2_HUMAN (111-434): 3.93e-52: 196: 36.31
+	Hs
		414806 LIS1_HUMAN (3-151): 7.87e-23: 99.9: 14.82		CDK1_HUMAN (108-434): 4.87e-121: 362: 27.76
+	Sc
		539289 YP247_YEAST (43-336): 2.17e-20: 94: 13.31		YAK1_YEAST (17-484): 4.75e-116: 366: 30.68
+	Hs
		625202 LIS1_HUMAN (3-151): 7.87e-23: 99.9: 14.82		CDK2_HUMAN (108-376): 5.32e-119: 357: 27.82
+	Hs
		1319415 WDR33_HUMAN (221-341): 6.91e-16: 81: 14.05		DYRK4_HUMAN (4-542): 1.03e-119: 367: 32.22
+	Dm
		618401 Q8SYL1_DROME (125-326): 1.89e-20: 93.7: 20.18		CDK1_DROME (108-434): 1.51e-115: 348: 27.76
+	Hs
		997818 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		HIPK4_HUMAN (111-440): 1.6e-50: 186: 37.68
+	Zm
		33426 Q8W514_MAIZE (17-342): 3.31e-57: 192: 13.83		A0A1D6L2E7_MAIZE (91-428): 6.38e-50: 189: 35.57