HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: DTL (Q9NZJ0)
Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)
Gene: DTL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	17041588
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0051726 - regulation of cell cycle
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 730
+	Hs
		903418 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		903349 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5B_HUMAN (190-502): 2.83e-55: 194: 16.51
+	Hs
		903077 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	Hs
		903428 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		792949 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		LIS1_HUMAN (260-499): 2.94e-36: 143: 15.23
+	Hs
		903551 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NLE1_HUMAN (343-590): 4e-15: 80.5: 10.97
+	Hs
		209416 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	Hs
		903500 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR12_HUMAN (227-403): 1.54e-14: 78.4: 20.00
+	Hs
		792935 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		LIS1_HUMAN (260-499): 2.94e-36: 143: 15.23
+	Mm
		925836 LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49		LIS1_MOUSE (260-499): 2.34e-36: 143: 15.23
+	Hs
		209467 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		1288273 WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Dm
		1358845 WDS_DROME (3-290): 7.53e-92: 279: 31.21		WDS_DROME (8-172): 1e-29: 123: 15.64
+	Hs
		1240442 POC1B_HUMAN (5-251): 5.05e-84: 263: 27.89		POC1A_HUMAN (256-429): 6.94e-28: 118: 24.71
+	Hs
		236250 WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83		PRP17_HUMAN (16-169): 9.6e-20: 95.8: 16.97
+	Dm
		1363493 Q9VYQ9_DROME (12-333): 2.1e-89: 277: 26.67		Q9VD52_DROME (206-403): 1.33e-12: 73: 16.50
+	Dm
		1363491 Q9VPL0_DROME (1-285): 1.56e-79: 247: 23.15		Q9VD52_DROME (206-403): 1.33e-12: 73: 16.50
+	Hs
		245633 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		TBL1X_HUMAN (9-129): 3.35e-16: 84.4: 12.14
+	Hs
		1309163 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		TBL1Y_HUMAN (345-587): 1.16e-12: 73.2: 12.95