HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: FZR1 (Q9UM11)
Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1)
Gene: FZR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32076268
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ANAPC4_WD40~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 496
+	Hs
		903418 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		FBXW7_HUMAN (87-424): 1.7e-71: 242: 18.68
+	Hs
		903551 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NLE1_HUMAN (52-385): 3.28e-60: 207: 16.32
+	Dm
		1358859 WDS_DROME (3-290): 7.53e-92: 279: 31.21		FBXW7_DROME (20-496): 6.04e-89: 298: 17.46
+	Hs
		792949 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		LIS1_HUMAN (309-495): 7.12e-53: 185: 19.68
+	Hs
		903428 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SNR40_HUMAN (32-339): 1.33e-49: 175: 15.89
+	Hs
		903077 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5_HUMAN (389-496): 1.49e-26: 111: 18.35
+	Hs
		792935 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		LIS1_HUMAN (309-495): 7.12e-53: 185: 19.68
+	Mm
		925836 LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49		LIS1_MOUSE (309-495): 5.38e-53: 185: 19.68
+	Hs
		903349 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5B_HUMAN (408-495): 1.82e-11: 67.3: 16.15
+	Hs
		209467 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		SNR40_HUMAN (32-339): 1.33e-49: 175: 15.89
+	Hs
		903176 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		CDC20_HUMAN (395-494): 7.34e-10: 63: 16.67
+	Hs
		1309163 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		TBL1Y_HUMAN (99-430): 2.64e-70: 234: 16.20
+	Hs
		1288273 WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83		SNR40_HUMAN (32-339): 1.33e-49: 175: 15.89
+	Dm
		1358845 WDS_DROME (3-290): 7.53e-92: 279: 31.21		WDS_DROME (389-496): 1.28e-24: 106: 17.43
+	Hs
		209416 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		WDR5_HUMAN (389-496): 1.49e-26: 111: 18.35
+	Mm
		1265755 PLRG1_MOUSE (2-333): 3.73e-85: 267: 26.12		FZR1_MOUSE (319-495): 2.95e-25: 110: 18.68
+	Hs
		209497 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		FZR1_HUMAN (319-495): 6.65e-25: 109: 18.68
+	Hs
		1240442 POC1B_HUMAN (5-251): 5.05e-84: 263: 27.89		POC1A_HUMAN (68-215): 1.37e-12: 71.1: 10.60