HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: KMT2B (Q9UMN6)
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
Gene: KMT2B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.985

The method score is based on:

Property Details
Experiments 27563068, 24981860, 33643786, 22665483, 26186194, 28514442, 27705803, 33022573, 33961781, 33472061, 20305087, 22266653, 23995757, 18840606, 24788516
Identification Methods pull down, affinity chromatography technology, unspecified method, x-ray crystallography, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification, isothermal titration calorimetry
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains SET~WD40
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0035097 - histone methyltransferase complex
GO:0042800 - histone H3K4 methyltransferase activity
GO:0044665 - MLL1/2 complex
and 1 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 334
Hs

1 2715
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024