HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: SET1B (Q9UPS6)
Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)
Gene: SETD1B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.980

Property	Details
Experiments	26496610, 27563068, 24981860, 17355966, 22665483, 26186194, 28514442, 27705803, 33022573, 33961781, 22266653
Identification Methods	affinity chromatography technology, pull down, unspecified method, x-ray crystallography, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	N-SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 334 Hs			1 1966
+	Hs
		903604 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2B_HUMAN (1069-1966): 4.68e-71: 268: 21.69
+	Hs
		903149 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Hs
		903374 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2C_HUMAN (1759-1966): 1.32e-58: 227: 37.04
+	Mm
		903669 WDR5_MOUSE (1-334): 2.77e-131: 379: 100.00		KMT2C_MOUSE (1759-1966): 6.65e-58: 225: 36.57
+	Hs
		165657 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SET1A_HUMAN (409-1966): 1e-54: 214: 22.13
+	Hs
		209441 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		EZH2_HUMAN (1464-1949): 9.8e-64: 235: 15.84
+	Dm
		1129076 WDS_DROME (3-290): 7.53e-92: 279: 31.21		SET1_DROME (30-197): 5.94e-53: 208: 38.60
+	At
		1319861 WDR5A_ARATH (2-241): 2.46e-75: 236: 27.82		ATX1_ARATH (1710-1966): 8.45e-64: 240: 31.03
+	Hs
		152622 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85
+	Sc
		744551 SWD3_YEAST (29-330): 8.4e-45: 157: 34.47		SET1_YEAST (1532-1966): 8.55e-67: 250: 27.37
+	Hs
		203735 DAW1_HUMAN (144-333): 8.06e-44: 157: 30.69		SUV91_HUMAN (1686-1965): 2.95e-70: 244: 17.93
+	Hs
		975303 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Hs
		1317584 NLE1_HUMAN (197-332): 1.05e-32: 128: 22.54		SETD2_HUMAN (1733-1965): 3.5e-58: 225: 24.07
+	Hs
		1080207 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		EZH2_HUMAN (1464-1949): 9.8e-64: 235: 15.84
+	Hs
		975304 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Zm
		35725 A0A1D6LQJ4_MAIZE (248-333): 5.86e-14: 73.4: 28.41		A0A1D6M742_MAIZE (1624-1963): 4.63e-62: 228: 17.44
+	Hs
		331862 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		NSD2_HUMAN (1654-1965): 6.33e-60: 230: 22.15
+	Hs
		1288291 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		SETD2_HUMAN (1733-1965): 3.5e-58: 225: 24.07
+	Hs
		152663 WDR5B_HUMAN (3-198): 4.87e-59: 194: 30.10		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85
+	Hs
		152678 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85