HitPredict

Interactor 1: WDR5 (P61965)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) (WD repeat-containing protein BIG-3)
Gene: WDR5

Interactor 2: NR0B1 (Q61066)
Nuclear receptor subfamily 0 group B member 1 (Nuclear receptor DAX-1)
Gene: NR0B1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	20362541
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 334 Mm			1 472
+	Hs
		782513 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		HNF4A_HUMAN (114-470): 5.58e-90: 283: 18.55
+	Mm
		903664 WDR5_MOUSE (1-334): 2.77e-131: 379: 100.00		ERR2_MOUSE (77-472): 5.64e-78: 251: 16.67
+	Hs
		369305 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		ESR1_HUMAN (72-471): 6.4e-72: 240: 14.78
+	Hs
		903403 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		ESR2_HUMAN (75-472): 3.18e-71: 236: 14.90
+	Hs
		903650 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NR2E3_HUMAN (123-470): 7.04e-69: 227: 17.79
+	Hs
		823801 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NR2C2_HUMAN (183-471): 9.44e-67: 226: 23.59
+	Hs
		209373 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		ESR1_HUMAN (72-471): 6.4e-72: 240: 14.78
+	Hs
		209465 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		ESR2_HUMAN (75-472): 3.18e-71: 236: 14.90
+	Hs
		209405 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		NR2C2_HUMAN (183-471): 9.44e-67: 226: 23.59
+	Hs
		245574 TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32		HNF4A_HUMAN (114-470): 5.58e-90: 283: 18.55
+	Hs
		488022 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		RARA_HUMAN (134-470): 7.03e-74: 241: 12.11
+	Hs
		370377 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		ESR1_HUMAN (72-471): 6.4e-72: 240: 14.78
+	Hs
		1269548 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		ESR2_HUMAN (75-472): 3.18e-71: 236: 14.90
+	Hs
		369932 WDR5B_HUMAN (3-198): 4.87e-59: 194: 30.10		ESR1_HUMAN (72-471): 6.4e-72: 240: 14.78
+	Hs
		369721 SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71		ESR1_HUMAN (72-471): 6.4e-72: 240: 14.78
+	Hs
		1103005 SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71		ESR2_HUMAN (75-472): 3.18e-71: 236: 14.90
+	Hs
		1269746 NLE1_HUMAN (197-332): 1.05e-32: 128: 22.54		ESR2_HUMAN (75-472): 3.18e-71: 236: 14.90
+	Hs
		488008 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		RARA_HUMAN (134-470): 7.03e-74: 241: 12.11
+	Hs
		824270 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		NR2C2_HUMAN (183-471): 9.44e-67: 226: 23.59
+	Hs
		525329 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		NR2C1_HUMAN (192-468): 3.7e-59: 206: 23.86