HitPredict

Interactor 1: WDR5 (P61965)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) (WD repeat-containing protein BIG-3)
Gene: WDR5

Interactor 2: KMT2C (Q8BRH4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog)
Gene: KMT2C

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	17500065
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0042393 - histone binding GO:0042800 - histone H3K4 methyltransferase activity and 1 others more... GO:0044666 - MLL3/4 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 334 Mm			1 4903
+	Hs
		903374 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2C_HUMAN (1-4903): 0: 1794: 84.43
+	Hs
		903444 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		EHMT2_HUMAN (3772-4899): 4.28e-115: 401: 12.93
+	Hs
		903234 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		CHD4_HUMAN (328-662): 5.75e-87: 321: 14.17
+	Hs
		165657 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SET1A_HUMAN (4630-4903): 2.82e-54: 214: 29.73
+	Dm
		1129076 WDS_DROME (3-290): 7.53e-92: 279: 31.21		SET1_DROME (4606-4903): 2.66e-64: 246: 27.89
+	At
		1319861 WDR5A_ARATH (2-241): 2.46e-75: 236: 27.82		ATX1_ARATH (4680-4903): 6.36e-69: 258: 31.58
+	Hs
		903609 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SET1B_HUMAN (4770-4903): 4.53e-24: 115: 51.11
+	Hs
		203735 DAW1_HUMAN (144-333): 8.06e-44: 157: 30.69		SUV91_HUMAN (4525-4902): 1.34e-97: 324: 17.73
+	Hs
		903604 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2B_HUMAN (229-331): 4.93e-18: 95.2: 28.16
+	Hs
		903149 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2A_HUMAN (231-331): 3.63e-17: 92.5: 31.68
+	Hs
		152622 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		KMT2D_HUMAN (2429-3432): 7.28e-15: 84.8: 9.33
+	Sc
		744551 SWD3_YEAST (29-330): 8.4e-45: 157: 34.47		SET1_YEAST (4522-4903): 4.78e-82: 298: 25.95
+	Hs
		1059779 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		CHD4_HUMAN (328-662): 5.75e-87: 321: 14.17
+	Hs
		209441 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		EZH2_HUMAN (4762-4884): 1.82e-15: 85.9: 37.40
+	Hs
		209466 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		REQU_HUMAN (358-434): 3.31e-12: 73.9: 41.25
+	Hs
		1018714 NLE1_HUMAN (197-332): 1.05e-32: 128: 22.54		CHD3_HUMAN (320-620): 4.71e-47: 190: 15.14
+	Hs
		152663 WDR5B_HUMAN (3-198): 4.87e-59: 194: 30.10		KMT2D_HUMAN (2429-3432): 7.28e-15: 84.8: 9.33
+	Hs
		975303 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		KMT2A_HUMAN (231-331): 3.63e-17: 92.5: 31.68
+	Hs
		1080207 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		EZH2_HUMAN (4762-4884): 1.82e-15: 85.9: 37.40
+	Hs
		152678 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		KMT2D_HUMAN (2429-3432): 7.28e-15: 84.8: 9.33