HitPredict

Interactor 1: LMO4 (P61968)
LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)
Gene: LMO4

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	24981860, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0021520 - spinal cord motor neuron cell fate specification GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 165 Hs			1 359
+	Hs
		1148484 LHX8_HUMAN (23-158): 3.95e-48: 160: 39.71		ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00
+	Hs
		899916 ISL1_HUMAN (22-162): 3.73e-39: 137: 36.55		ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91
+	Hs
		899930 ISL1_HUMAN (22-162): 3.73e-39: 137: 36.55		ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00
+	Dm
		114751 P92031_DROME (21-141): 3.63e-48: 164: 41.46		M9PD53_DROME (21-265): 2.59e-52: 183: 33.74
+	Dm
		1368258 Q9VJ37_DROME (21-141): 2.89e-48: 165: 41.46		Q9VJ00_DROME (21-265): 3.35e-52: 182: 33.74
+	Hs
		903736 LHX8_HUMAN (23-158): 3.95e-48: 160: 39.71		LMO4_HUMAN (15-165): 1.69e-54: 178: 38.13
+	Mm
		903797 LMO4_MOUSE (1-165): 1.95e-43: 143: 100.00		LMO4_MOUSE (15-165): 1.69e-54: 178: 38.13
+	Ce
		104771 LIN11_CAEEL (7-156): 1.29e-39: 139: 29.14		LIM7_CAEEL (8-354): 1.2e-51: 179: 31.33
+	Ce
		104772 HM14_CAEEL (1-157): 1.01e-39: 138: 28.30		LIM7_CAEEL (8-354): 1.2e-51: 179: 31.33
+	Ce
		447531 HM14_CAEEL (1-157): 1.01e-39: 138: 28.30		MEC3_CAEEL (25-279): 1.09e-42: 152: 24.11
+	Hs
		638491 LMO4_HUMAN (1-165): 1.95e-43: 143: 100.00		RBTN1_HUMAN (27-143): 3.27e-26: 103: 40.83
+	Dm
		112552 Q9VJ37_DROME (21-141): 2.89e-48: 165: 41.46		M9NCY1_DROME (1-83): 1.31e-15: 79.3: 26.19
+	Hs
		1148497 LHX8_HUMAN (23-158): 3.95e-48: 160: 39.71		LHX6_HUMAN (7-81): 1.54e-11: 66.9: 20.00
+	Hs
		903763 LMO4_HUMAN (1-165): 1.95e-43: 143: 100.00		LHX4_HUMAN (1-82): 3.14e-17: 83.9: 22.89
+	Hs
		899927 ISL1_HUMAN (22-162): 3.73e-39: 137: 36.55		LMX1A_HUMAN (7-83): 2.7e-17: 84.3: 20.78
+	Hs
		899929 ISL1_HUMAN (22-162): 3.73e-39: 137: 36.55		LHX4_HUMAN (1-82): 3.14e-17: 83.9: 22.89
+	Hs
		899935 ISL1_HUMAN (22-162): 3.73e-39: 137: 36.55		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Mm
		839895 ISL1_MOUSE (22-162): 3.73e-39: 137: 36.55		LHX3_MOUSE (1-82): 6.09e-14: 74.3: 20.48
+	Ce
		590580 HM14_CAEEL (1-157): 1.01e-39: 138: 28.30		HM14_CAEEL (7-90): 1.7e-13: 72.7: 18.61