HitPredict

Interactor 1: NTF2 (P61970)
Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15)
Gene: NUTF2

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.978

Property	Details
Experiments	25416956, 28514442, 9533885, 33961781, 35271311, 20805321, 15522285, 10228171, 19098896, 24855949
Identification Methods	two hybrid, affinity chromatography technology, x-ray crystallography, pull down, comigration in non denaturing gel electrophoresis, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	NTF2~Ras
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus GO:0006611 - protein export from nucleus GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 127 Hs			1 216
+	At
		784993 NTF2A_ARATH (6-122): 5.23e-46: 146: 39.50		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	At
		784990 NTF2B_ARATH (6-122): 1.96e-44: 142: 40.83		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	Hs
		918860 G3BP1_HUMAN (4-127): 3.72e-50: 166: 22.96		RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00
+	Zm
		44510 A0A1D6Q2L8_MAIZE (5-124): 6.39e-48: 161: 22.66		B4FB55_MAIZE (6-206): 1.98e-79: 238: 25.85
+	Mm
		903860 NTF2_MOUSE (1-127): 3.29e-51: 160: 100.00		RAN_MOUSE (1-216): 7.75e-79: 237: 100.00
+	Rn
		903863 NTF2_RAT (1-127): 3.29e-51: 160: 100.00		RAN_RAT (1-216): 7.75e-79: 237: 100.00
+	Sc
		698753 NTF2_YEAST (3-122): 3.22e-42: 137: 42.62		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Hs
		919278 NXT2_HUMAN (6-123): 6.69e-39: 129: 24.22		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00